abstract：Background:To investigate the expression of RASSF-1A in oral squamous cell carcinoma (OSCC) and adjacent tissues, and to explore its mechanism of action in the development of OSCC. Methods:RASSF-1A and proliferation-related protein expression in clinical and OSCC mouse models were detected by qPCR and western blot. In...

journal_title：Cancer cell international

authors： Sun J

更新日期：2019-08-13 00:00:00

abstract：Background:Abnormal expressions of long noncoding RNAs (lncRNAs) are very common in clear cell renal cell carcinoma (ccRCC), and some of these have been reported to be highly correlated with prognosis of ccRCC patients. Methods:"edgeR" AND "DEseq" R packages were used to explore differentially expressed genes (DEGs) b...

journal_title：Cancer cell international

authors： Jiang W,Guo Q,Wang C,Zhu Y

更新日期：2019-08-05 00:00:00

abstract：Background:Carcinoma-associated fibroblasts (CAFs) are dominant components of tumor microenvironment, which has been reported to promote development, progression, and metastasis of cancer. However, the role of CAFs during adhesion process remains unknown. It has been hypothesized that CAFs contribute to adhesion to end...

journal_title：Cancer cell international

authors： Zhang R,Qi F,Shao S,Li G,Feng Y

更新日期：2019-07-24 00:00:00

abstract：Background:Renal cell carcinoma (RCC) is the most common kidney cancer and includes several molecular and histological subtypes with different clinical characteristics. The combination of DNA methylation and gene expression data can improve the classification of tumor heterogeneity, by incorporating differences at the ...

journal_title：Cancer cell international

authors： Chen W,Zhuang J,Wang PP,Jiang J,Lin C,Zeng P,Liang Y,Zhang X,Dai Y,Diao H

更新日期：2019-07-16 00:00:00

abstract：Background:Cancer cell viability is strongly modulated by the Hippo pathway, which includes mammalian STE20-like protein kinase 1 (Mst1) and yes-associated protein (Yap). Although the roles of Mst1 and Yap in thyroid carcinoma cell death have been fully addressed, no study has determined whether differential modificati...

journal_title：Cancer cell international

authors： Zhang X,Li F,Cui Y,Liu S,Sun H

更新日期：2019-05-22 00:00:00

abstract：:Non-small-cell lung cancer (NSCLC) is a type of malignancy with progressive metastasis having poor prognosis and lowered survival resulting from late diagnosis. The therapeutic approaches for the treatment of this incurable cancer are chemo- and radiotherapy. Since current treatments are insufficient and because of dr...

journal_title：Cancer cell international

authors： Pourhanifeh MH,Sharifi M,Reiter RJ,Davoodabadi A,Asemi Z

更新日期：2019-05-16 00:00:00

abstract：Background:Many epidemiological studies have investigated association of AXIN2 variants on overall cancer risks; however, the available results remain inconsistent. Methods:An updated analysis was conducted to ascertain a more accurate estimation of the correlation between AXIN2 148 C/T, 1365 C/T, and rs4791171 A/G po...

journal_title：Cancer cell international

authors： Xu B,Yuan W,Shi L,Zuo L,Wu XY,Zhang W,Wen Q

更新日期：2019-05-06 00:00:00

abstract：Background:miR-429 and TLN1 have been shown to affect the biological behaviours of many carcinomas. However, their effects in nasopharyngeal carcinoma (NPC) are not yet clear. Here, we investigated their regulatory relationships and effects on NPC cells. Methods:TargetScan was used to predict the regulatory relationsh...

journal_title：Cancer cell international

authors： Wang Z,Zhu Z,Lin Z,Luo Y,Liang Z,Zhang C,Chen J,Peng P

更新日期：2019-04-30 00:00:00

abstract：Background:MicroRNAs have been involved in regulating crucial biological function in some tumors. However, the clinical role and functional effects of miR-591 in breast cancer remain unknown. Methods:The expression of miR-591 was detected in breast cancer tissues and their paired normal tissues by qRT-PCR. Functional ...

journal_title：Cancer cell international

authors： Huang X,Tang F,Weng Z,Zhou M,Zhang Q

更新日期：2019-04-24 00:00:00

abstract：Background:Tumor necrosis factor-a-induced protein 8 (TNFAIP8) presented a elevated expression in endometrial cancer (EC). However, the relationship of TNFAIP8 gene polymorphisms with EC risk remains unclear. This case-control study aimed to investigate the effect of single nucleotide polymorphisms (SNPs) in TNFAIP8 on...

journal_title：Cancer cell international

authors： Liu T,Jiang L,Yu L,Ge T,Wang J,Gao H

更新日期：2019-04-23 00:00:00

abstract：Background:Lung adenocarcinoma (LUAD) patients experiencing lymph node metastasis (LNM) always exhibit poor clinical outcomes. A biomarker or gene signature that could predict survival in these patients would have a substantial clinical impact, allowing for earlier detection of mortality risk and for individualized the...

journal_title：Cancer cell international

authors： Wang Y,Zhang Q,Gao Z,Xin S,Zhao Y,Zhang K,Shi R,Bao X

更新日期：2019-04-16 00:00:00

abstract：:[This corrects the article DOI: 10.1186/s12935-019-0742-0.]. ...

journal_title：Cancer cell international

authors： Ma MH,An JX,Zhang C,Liu J,Liang Y,Zhang CD,Zhang Z,Dai DQ

更新日期：2019-04-11 00:00:00

abstract：Background:Breast cancer is one of the most common malignancy among females from the worldwide cancer incidence statistics. Peroxisome gamma coactivator-1β (PGC-1β) has long been identified to be involved in this type of tumorigenesis. However, the mechanisms of PGC-1β in human breast cancer have not been fully underst...

journal_title：Cancer cell international

authors： Cao J,Wang X,Wang D,Ma R,Li X,Feng H,Wang J,Liu S,Wang L

更新日期：2019-04-11 00:00:00

abstract：Background:In addition to morphological and cytogenetic features, acute myeloid leukemias are characterized by mutations that can be used for target-therapy; also the minimal/measurable residual disease (MRD) could be an important prognostic factor. The purpose of this retrospective study was to investigate if somatic ...

journal_title：Cancer cell international

authors： Salehzadeh S,Guerrini F,Pizzano U,Grassi S,Ciabatti E,Iovino L,Buda G,Caracciolo F,Benedetti E,Orciuolo E,Pelosini M,Consani G,Carulli G,Metelli MR,Martini F,Mazziotta F,Mazzantini E,Rossi P,Tavarozzi R,Ricci F,Pe

更新日期：2019-04-04 00:00:00

abstract：Background:It is well known that hepatocellular carcinoma (HCC) has been one of the most life-threatening diseases all over the world. Plenty of internal and extrinsic factors have been proven to be related to HCC, such as gene mutation, viral hepatitis, and Nitrosamines. Though previous studies demonstrated that gluta...

journal_title：Cancer cell international

authors： Li S,Xue F,Zheng Y,Yang P,Lin S,Deng Y,Xu P,Zhou L,Hao Q,Zhai Z,Wu Y,Dai Z,Chen S

更新日期：2019-03-29 00:00:00

abstract：Background:Laryngopharyngeal reflux (LPR), with its increasing morbidity, is attracting considerable attention. In recent years, the causal role between LPR and laryngeal carcinoma has been debated. The main harmful component of LPR is pepsin, which has been shown to induce mucosal inflammation by damaging the mucous m...

journal_title：Cancer cell international

authors： Tan JJ,Wang L,Mo TT,Wang J,Wang MG,Li XP

更新日期：2019-03-20 00:00:00

abstract：Background:Tumor necrosis factor-α (TNF-α) immunotherapy controls the progression of human cervical cancer. Here, we explored the detailed molecular mechanisms played by melatonin in human cervical cancer (HeLa cells) death in the presence of TNF-α injury, with a particular attention to the mitochondrial homeostasis. ...

journal_title：Cancer cell international

authors： Zhao Q,Wang W,Cui J

更新日期：2019-03-14 00:00:00

abstract：Background:Emergence of resistance to molecular targeted therapy constitutes a limitation to clinical benefits in cancer treatment. Cross-resistance commonly happens with chemotherapeutic agents but might not with targeted agents. Methods:In the current study, TP53 wild-type cell lines with druggable MAPK pathway muta...

journal_title：Cancer cell international

authors： Wu CE,Koay TS,Ho YH,Lovat P,Lunec J

更新日期：2019-03-07 00:00:00

abstract：Background:Pancreatic cancer (PC) remains one of the most aggressive cancers worldwide. However, genetic factors underlying PC susceptibility remain largely unclear. Long noncoding RNA (lncRNA) HOX transcript antisense RNA (HOTAIR) acts as an oncogene and its genetic variation has been linked to many cancers. However, ...

journal_title：Cancer cell international

authors： Jiang D,Xu L,Ni J,Zhang J,Cai M,Shen L

更新日期：2019-02-28 00:00:00

abstract：Background:Thyroid cancer is the most common type of endocrine malignancy and the incidence rate is rapidly increasing worldwide. Epigallocatechin-3-gallate (EGCG) could suppress cancer growth and induce apoptosis in many types of cancer cells. However, the mechanism of action of EGCG on the growth of human thyroid car...

journal_title：Cancer cell international

authors： Wu D,Liu Z,Li J,Zhang Q,Zhong P,Teng T,Chen M,Xie Z,Ji A,Li Y

更新日期：2019-02-28 00:00:00

abstract：Background:The staging system of nasopharyngeal carcinoma (NPC) has close relationship with the degree of cell differentiation, but most NPC patients remain undiagnosed until advanced phases. Novel metabolic markers need to be characterized to support diagnose at an early stage. Methods:Metabolic characteristics of na...

journal_title：Cancer cell international

authors： Chen Y,Chen Z,Su Y,Lin D,Chen M,Feng S,Zou C

更新日期：2019-02-18 00:00:00

abstract：Background:Angioimmunoblastic T cell lymphoma (AITL) is a distinct subtype of peripheral T cell lymphoma and associated with poor outcomes. The activation status of T cell receptor (TCR) signaling has recently become a focus of attention in terms of the therapeutic targets. However, the molecular pathogenesis mechanism...

journal_title：Cancer cell international

authors： Liu Y,Wang X,Deng L,Ping L,Shi Y,Zheng W,Lin N,Wang X,Tu M,Xie Y,Liu W,Ying Z,Zhang C,Pan Z,Wang X,Ding N,Song Y,Zhu J

更新日期：2019-02-14 00:00:00

abstract：Background:This study aims to investigate the role of microRNA-92a (miR-92a) in metastasis of osteosarcoma (OS) cells in vivo and in vitro by regulatingTCF21 with the transmission of bone marrow derived mesenchymal stem cells (BMSCs). Methods:BMSCs were isolated, purified and cultured from healthy adult bone marrow ti...

journal_title：Cancer cell international

authors： Cao S,Jiang L,Shen L,Xiong Z

更新日期：2019-02-12 00:00:00

abstract：Background:Hepatocellular carcinoma (HCC) is one of the most common malignancies with a high morbidity and mortality worldwide. MicroRNAs are key regulators of HCC genesis. However, the regulatory role and underlying mechanisms of microRNA in HCC is still limited. Methods:Cyclin B1 (CCNB1) mRNA levels were examined in...

journal_title：Cancer cell international

authors： Gu J,Liu X,Li J,He Y

更新日期：2019-01-14 00:00:00

abstract：Background:T-acute lymphoblastic leukemia (T-ALL) was a hematological malignancy characterized by the accumulation of immature T cells in bone marrow and peripheral blood. In this study, we tried to explore the physiological role of CD59 in T-ALL. Methods:In this study, we collected the bone marrow samples from 17 T-A...

journal_title：Cancer cell international

authors： Jia Y,Qi Y,Wang Y,Ma X,Xu Y,Wang J,Zhang X,Gao M,Cong B,Han S

更新日期：2019-01-08 00:00:00

abstract：Background:The ubiquitin-specific protease 28 (USP28) is an oncogenic deubiquitinase, which plays a critical role in tumorigenesis via antagonizing the ubiquitination and degradation of tumor suppressor protein FBXW7-mediated oncogenic substrates. USP28 controls hypoxia-dependent angiogenesis and metastasis by preventi...

journal_title：Cancer cell international

authors： Du SC,Zhu L,Wang YX,Liu J,Zhang D,Chen YL,Peng Q,Liu W,Liu B

更新日期：2019-01-03 00:00:00

abstract：Background:Programmed cell death 1 (PD-1) functions as an immune checkpoint in the process of anti-tumor immune response. The PD-1 blockade is now becoming a fundamental part in cancer immunotherapy. So it's essential to elicit the PD-1 related immune process in different types of cancer. Methods:The Cancer Genome Atl...

journal_title：Cancer cell international

authors： Shang J,Song Q,Yang Z,Sun X,Xue M,Chen W,Yang J,Wang S

更新日期：2018-12-27 00:00:00

abstract：Background:Acute myeloid leukemia (AML) is a clinically and biologically heterogeneous disease. The survival of older patients is generally poor. In the current study, we sought to investigate the differences in molecular gene mutations between younger and older AML patients, and to identify those newly diagnosed AML p...

journal_title：Cancer cell international

authors： Cao XX,Cai H,Mao YY,Wu Q,Zhang L,Zhou DB,Li J

更新日期：2018-12-22 00:00:00

abstract：Background:Glioma is the most common highly aggressive, primary adult brain tumour. Clinical data show that therapeutic approaches cannot reach the expectations in patients, thus gliomas are mainly incurable diseases. Tumour cells can adapt rapidly to alterations during therapeutic treatments related to their metabolic...

journal_title：Cancer cell international

authors： Petővári G,Hujber Z,Krencz I,Dankó T,Nagy N,Tóth F,Raffay R,Mészáros K,Rajnai H,Vetlényi E,Takács-Vellai K,Jeney A,Sebestyén A

更新日期：2018-12-19 00:00:00

abstract：Background:Schwannoma arising from peripheral nervous sheaths is a benign tumor. Methods:To evaluate cell cytotoxicity, (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) tetrazolium reduction and terminal deoxynucleotidyltransferase UTP nick-end labeling (TUNEL) assays were used. A microRNA (miRNA) array ...

journal_title：Cancer cell international

authors： Sohn EJ,Bak KM,Nam YK,Park HT

更新日期：2018-12-04 00:00:00

abstract：Background:Helicobacter pylori (H. pylori)-induced gastric cancer is an intricate progression of immune response against H. pylori infection. IL-16, TGF-β1 and TLR4 pathways were the mediators involved in the immune response. We hypothesized that genetic variations in genes of these pathways have potential susceptibili...

journal_title：Cancer cell international

authors： He B,Xu T,Pan B,Pan Y,Wang X,Dong J,Sun H,Xu X,Liu X,Wang S

更新日期：2018-11-20 00:00:00

abstract：Background:Chimeric antigen receptors (CARs) represent a novel facet of modern day synthetic biology that exemplifies personalized medicine at work through their ability to harness and redirect a patient's immune system to fight cancer. Body:By combining the target-specificity of antibodies to the effector capabilitie...

journal_title：Cancer cell international

authors： Leyfman Y

更新日期：2018-11-14 00:00:00

abstract：Background:Nuclear transcription factor kappa B (NF-κB) subunits exhibit crucial roles in tumorigenesis and chemo-sensitivity. Recent studies suggest that RelB, the key subunit of the alternative NF-κB pathway, plays a critical role in the progression of diverse human malignancies. However, the significance of RelB in ...

journal_title：Cancer cell international

authors： Zhou X,Shan Z,Yang H,Xu J,Li W,Guo F

更新日期：2018-11-13 00:00:00

abstract：Background:Breast cancer has been the first death cause of cancer in women all over the world. Metastasis is believed to be the most important process for treating breast cancer. There is evidence that lncRNA MEG3 functions as a tumor suppressor in breast cancer metastasis. However, upstream regulation of MEG3 in breas...

journal_title：Cancer cell international

authors： Wang XX,Guo GC,Qian XK,Dou DW,Zhang Z,Xu XD,Duan X,Pei XH

更新日期：2018-10-25 00:00:00

abstract：Background:The aim of the study was to explore the association between the SIRT1 single nucleotide polymorphism (SNP) rs3758391 and diffuse large B cell lymphoma (DLBCL) in a Chinese Han population. Methods:206 patients diagnosed with DLBCL and 219 healthy individuals were recruited in the present study. The genotypin...

journal_title：Cancer cell international

authors： Kan Y,Ge P,Wang X,Xiao G,Zhao H

更新日期：2018-10-22 00:00:00

abstract：:Osteosarcoma (OS) is one of the most prevalent malignant cancers with lower survival and poor overall prognosis mainly in children and adolescents. Identifying the molecular mechanisms and OS stem cells (OSCs) as new concepts involved in disease pathogenesis and progression may potentially lead to new therapeutic targ...

journal_title：Cancer cell international

authors： Otoukesh B,Boddouhi B,Moghtadaei M,Kaghazian P,Kaghazian M

更新日期：2018-10-16 00:00:00

abstract：Background:Breast cancer is the leading cause of oncological mortality among women. Efficient detection of cancer cells in an early stage and potent therapeutic agents targeting metastatic tumors are highly needed to improve survival rates. Emerging evidence indicates that lncRNAs (long noncoding RNAs) are critical reg...

journal_title：Cancer cell international

authors： Hou L,Tu J,Cheng F,Yang H,Yu F,Wang M,Liu J,Fan J,Zhou G

更新日期：2018-09-18 00:00:00

abstract：Background:SOX2 overlapping transcript (SOX2OT) is a long non-coding RNA, over-expressed in human tumor tissues and embryonic cells. Evidences support its function in the cell cycle; however there is no clear mechanism explaining its function in cell proliferation regulation. Here we investigated cancer cell response t...

journal_title：Cancer cell international

authors： Saghaeian Jazi M,Samaei NM,Mowla SJ,Arefnezhad B,Kouhsar M

更新日期：2018-09-05 00:00:00

abstract：Background:Growing evidence suggests that MiRNAs play essential roles in the initiation and progression of colorectal cancer (CRC). The aberrant expression of miR-384 has been reported in some cancers. However, the role and mechanism of miR-384 in CRC proliferation remains unknown. Methods:The expression of miR-384 wa...

journal_title：Cancer cell international

authors： Wang YX,Zhu HF,Zhang ZY,Ren F,Hu YH

更新日期：2018-09-03 00:00:00

abstract：:Cancer is a major public health problem as one of the leading causes of death worldwide. Deciphering the molecular regulation mechanisms of tumor progression can make way for tumor diagnosis and therapy. Paternally expressed gene 10 (PEG10), located on human chromosome 7q21.3, has turned out to be an oncogene implicat...

journal_title：Cancer cell international

authors： Xie T,Pan S,Zheng H,Luo Z,Tembo KM,Jamal M,Yu Z,Yu Y,Xia J,Yin Q,Wang M,Yuan W,Zhang Q,Xiong J

更新日期：2018-08-13 00:00:00